Genotypisierung beim Schaf
Like BSE, scrapie is among the progressive, contagious and fatal diseases of the brain. It is caused by pathologically altered proteins (prions) that damage the nerve cells. The disease is transmitted by contaminated water or fodder (also pastures), etc.
A DNA analysis is conducted on a blood sample to determine the genotype and hence to assess the scrapie risk. Certain mutations in the prion cell of the sheep (ovine PrPc) lead to an elevated disease risk.
The genotypes are assigned to 5 risk groups (G1-G5). The G1 group is practically resistant to scrapie and also does not present a risk for following generations. Above group G3, the risk to the individual animal rises.
Awareness of the scrapie genotype is an essential factor in sheep breeding.
Spider Lamb Syndrome (SLS) leads to skeletal deformation in lambs. It is caused by a genetic defect that the lamb inherits from both of its parents. A sheep carrying just one defective gene is healthy, but still a disease vector. Its young may contract SLS.
Awareness of the SLS genotype is recommended in sheep breeding.
Suitable samples include EDTA blood or tissue from the animal’s ear.